Multiple Sclerosis vs. Atherosclerosis: What’s the Difference and Is There a Connection?
May 19, 2025 | Brain and Spine Specialists

Why These Two Conditions Get Confused
If you’ve ever heard of multiple sclerosis (MS) and atherosclerosis, you might wonder if they’re related. After all, the names sound quite similar, and both involve inflammation. But while they share this common characteristic, they are very different diseases affecting different parts of the body.
Multiple sclerosis is a neurological condition where the immune system mistakenly attacks the protective covering of nerve fibers in the brain and spinal cord, leading to a range of symptoms. Atherosclerosis, on the other hand, is a cardiovascular condition where plaque builds up inside the arteries, restricting blood flow and causing heart-related issues.
Even though the terms multiple sclerosis and atherosclerosis both refer to inflammation, their effects on the body couldn’t be more different. This blog will break it down clearly so you can understand the key differences, overlapping risk factors, and the symptoms to watch for.
Quick Comparison: MS vs. Atherosclerosis
Here’s a quick visual comparison to help you better understand the key differences between multiple sclerosis and atherosclerosis:
Feature | Multiple Sclerosis (MS) | Atherosclerosis |
What it affects | Brain and spinal cord (CNS) | Arteries |
Cause | Immune system attacks nerve fibers | Plaque buildup in arteries |
Type of disease | Neurological | Cardiovascular |
Involves inflammation? | Yes | Yes |
Common symptoms | Numbness, fatigue, vision problems | Chest pain, high blood pressure |
Treatment | Immunotherapy, steroids | Lifestyle changes, medications |
While both diseases involve inflammation, they affect the body in very different ways. MS impacts the brain and spinal cord, while atherosclerosis affects the arteries, which are part of the cardiovascular system.
Is There a Connection Between MS and Atherosclerosis?
You might be wondering if there’s any direct link between MS and atherosclerosis. While both conditions involve chronic inflammation, they impact the body in distinct ways.
For people with MS, it’s important to note that they are not immune to cardiovascular disease. In fact, the reduced physical activity that often comes with MS, as well as long-term steroid use and shared risk factors, may increase the risk of developing atherosclerosis. However, MS itself does not cause atherosclerosis, and a person can have both conditions.
Can You Have Both MS and Atherosclerosis? Yes, it’s possible, especially as people with MS age. If you have MS, it’s a good idea to talk to your healthcare provider about monitoring your heart health. Regular checkups and a proactive approach to managing your cardiovascular risk factors can help catch any issues early.
How MS Can Impact Your Heart
Many patients with MS wonder how their condition might affect their heart. While MS is not a heart disease, it can impact the heart’s function, particularly through the nervous system. Here are some key questions to help you understand the relationship between MS and heart health:
Does MS affect the heart?
MS can influence the autonomic nervous system, which controls heart rate and blood pressure. This means that while MS doesn’t directly cause heart disease, it can affect how the heart functions.
Can MS cause high blood pressure?
MS itself doesn’t directly cause high blood pressure, but changes in activity levels, stress, or medications (like steroids) can contribute to fluctuations in blood pressure. It’s important to monitor these factors.
What are MS heart symptoms?
Some MS patients report heart-related symptoms, such as irregular heartbeat, dizziness, fatigue, and fluctuating blood pressure. These symptoms may be related to nervous system changes rather than heart disease itself.
While MS doesn’t directly cause heart problems, its effects on the nervous system can influence heart function. If you’re experiencing symptoms like dizziness or irregular heartbeats, be sure to discuss them with your doctor.
What to Ask Your Doctor
It’s essential to advocate for your health, especially if you have MS or concerns about your heart. Here’s a list of questions to consider asking your healthcare provider:
- Are my symptoms related to MS, heart issues, or something else?
- Should I be screened for heart disease even if I have MS?
- Could my MS medications affect my blood pressure or cholesterol?
- What can I do to reduce my risk for both conditions?
- Who should I see for these concerns — a neurologist, a cardiologist, or both?
These questions can help you work with your doctor to ensure that both your brain and heart health are being properly managed.
Summary: Know the Differences, Watch for the Overlap
Although multiple sclerosis and atherosclerosis both involve inflammation, the way they affect the body is quite different. MS targets the brain and spinal cord, while atherosclerosis affects the cardiovascular system. It’s also important to be aware that people with MS may be at higher risk for heart problems due to reduced activity and medication side effects.
By staying informed, asking the right questions, and keeping an open dialogue with your healthcare team, you can effectively manage both MS and your overall heart health.
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